A novel allele, HLA-C*15:227, identified when typing COVID-19 patients

HLA. 2021 Apr;97(4):377-378. doi: 10.1111/tan.14199. Epub 2021 Feb 8.

Abstract

HLA-C*15:227 differs from HLA-C*15:02:01:01 by a single nonsynonymous change (368A → G Tyrosine 99 to Cysteine).

Keywords: HLA-C*15:227; NGS HLA typing; novel HLA allele.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • COVID-19 / genetics*
  • COVID-19 / immunology
  • Databases, Genetic
  • HLA-C Antigens / classification
  • HLA-C Antigens / genetics*
  • High-Throughput Nucleotide Sequencing
  • Histocompatibility Testing
  • Humans
  • Polymorphism, Single Nucleotide*
  • Russia
  • Sequence Analysis, DNA
  • Terminology as Topic

Substances

  • HLA-C Antigens
  • HLA-C*15 antigen