Hemodynamic compromise developed following intentional overdose with nadolol in a 57-year-old woman. Nadolol is a nonselective beta-adrenergic blocking agent. Intravenous infusion of glucagon hydrochloride was effective in restoring hemodynamic stability after intravenous fluid loading and catecholamine infusions had failed. To our knowledge, this is the first reported case of nadolol overdose.