Roles of SDE2 and TIMELESS at active and stalled DNA replication forks

Natalie Lo; Julie Rageul; Hyungjin Kim

doi:10.1080/23723556.2020.1855053

Roles of SDE2 and TIMELESS at active and stalled DNA replication forks

Mol Cell Oncol. 2020 Dec 14;8(1):1855053. doi: 10.1080/23723556.2020.1855053. eCollection 2021.

Authors

Natalie Lo¹, Julie Rageul¹, Hyungjin Kim^{1

2}

Affiliations

¹ Department of Pharmacological Sciences, The State University of New York at Stony Brook, Stony Brook, NY, USA.
² Stony Brook Cancer Center, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA.

Abstract

The fork protection complex (FPC), comprising the TIMELESS (TIM)-TIPIN heterodimer, acts as a scaffold of the replisome to support seamless DNA replication. We recently showed that SDE2, a PCNA-associated DNA replication stress regulator, maintains the integrity of the FPC, and together with TIM, protects stalled replication forks from nucleolytic degradation.

Keywords: BRCA1/BRCA2; DNA replication stress; Genome instability; SDE2; TIMELESS; fork protection complex.

Grants and funding

R01 CA218132/CA/NCI NIH HHS/United States