The Role of Granulocyte Transfusions in Optimizing Candidacy for Chimeric Antigen Receptor T-cell Therapy in Patients With Treatment-refractory Infections

Francesco P Tambaro; Dristhi Ragoonanan; Priti Tewari; Demetrios Petropoulos; Fleur M Aung; Kris M Mahadeo; Sajad Khazal

doi:10.1097/MPH.0000000000002111

The Role of Granulocyte Transfusions in Optimizing Candidacy for Chimeric Antigen Receptor T-cell Therapy in Patients With Treatment-refractory Infections

J Pediatr Hematol Oncol. 2022 Mar 1;44(2):e463-e466. doi: 10.1097/MPH.0000000000002111.

Authors

Francesco P Tambaro^{1

2}, Dristhi Ragoonanan³, Priti Tewari¹, Demetrios Petropoulos¹, Fleur M Aung⁴, Kris M Mahadeo¹, Sajad Khazal¹

Affiliations

¹ Department of Pediatrics, Pediatric Stem Cell Transplantation and Cellular Therapy, CARTOX Program.
² Bone Marrow Transplant Unit, Pediatric Oncology Department, AORN Santobono Pausilipon, Naples, Italy.
³ Department of Pediatrics.
⁴ Department of Laboratory Medicine, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.

PMID: 33625094
DOI: 10.1097/MPH.0000000000002111

Abstract

While advancements in cellular therapy have improved outcomes for patients with refractory leukemia, severe infections may hinder access. Granulocyte transfusions, in combination with anti-microbial therapy, may be a safe option to facilitate candidacy for chimeric antigen receptor T-cell therapy in patients with leukemia and prolonged immune-compromised status.

MeSH terms

Cell- and Tissue-Based Therapy
Granulocytes
Humans
Immunotherapy, Adoptive
Leukemia*
Receptors, Antigen, T-Cell
Receptors, Chimeric Antigen*

Substances

Receptors, Antigen, T-Cell
Receptors, Chimeric Antigen