BDNF serum concentrations in 2053 participants of the Berlin Aging Study II

Golo Kronenberg; Karen Gertz; Johanna Schöner; Lars Bertram; Thomas Liman; Elisabeth Steinhagen-Thiessen; Ilja Demuth; Matthias Endres; Rainer Hellweg

doi:10.1016/j.neurobiolaging.2021.01.020

BDNF serum concentrations in 2053 participants of the Berlin Aging Study II

Neurobiol Aging. 2021 May:101:221-223. doi: 10.1016/j.neurobiolaging.2021.01.020. Epub 2021 Feb 2.

Authors

Golo Kronenberg¹, Karen Gertz², Johanna Schöner³, Lars Bertram⁴, Thomas Liman², Elisabeth Steinhagen-Thiessen⁵, Ilja Demuth⁶, Matthias Endres⁷, Rainer Hellweg⁸

Affiliations

¹ College of Life Sciences, University of Leicester, Leicester, UK; Leicestershire Partnership National Health Service Trust, Leicester, UK. Electronic address: gdk7@leicester.ac.uk.
² Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie und Centrum für Schlaganfallforschung Berlin (CSB), Berlin, Germany.
³ Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie und Centrum für Schlaganfallforschung Berlin (CSB), Berlin, Germany; Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik und Poliklinik für Psychiatrie und Psychotherapie, Berlin, Germany.
⁴ Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany; Department of Psychology, University of Oslo, Oslo, Norway.
⁵ Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center, Germany.
⁶ Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center, Germany; Charité - Universitätsmedizin Berlin, BCRT - Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany.
⁷ Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie und Centrum für Schlaganfallforschung Berlin (CSB), Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Berlin, Germany; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Berlin, Germany.
⁸ Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik und Poliklinik für Psychiatrie und Psychotherapie, Berlin, Germany.

PMID: 33636574
DOI: 10.1016/j.neurobiolaging.2021.01.020

Abstract

Serum BDNF concentrations in 2053 participants of the Berlin Aging Study II (BASE-II; 1572 individuals from the older age group [60-85 years], 481 individuals from the younger-age reference group [22-37 years]) were studied. There was no effect of age, sex, body mass index, self-reported depression, or BDNF Val66Met variant on serum BDNF concentrations. Multiple linear regression analysis failed to detect significant relationships of Digit Symbol Substitution Test score and Consortium to Establish a Registry for Alzheimer's Disease memory score to BDNF levels. However, we detected a positive correlation between platelet counts and BDNF levels (r = 0.303, p < 0.001). Our findings do not support an effect of aging, self-reported depression, or the Val66Met variant on serum BDNF concentrations. The role of thrombocytes in the biology of serum BDNF merits further study.

Keywords: Aging; Brain-derived neurotrophic factor; Depression; Platelet.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Aging / blood*
Alzheimer Disease / diagnosis*
Berlin
Biomarkers / blood
Blood Platelets / metabolism
Brain-Derived Neurotrophic Factor / blood*
Brain-Derived Neurotrophic Factor / genetics
Female
Genetic Variation
Humans
Linear Models
Male
Middle Aged
Platelet Count

Substances

Biomarkers
Brain-Derived Neurotrophic Factor