Epigenetic Dysregulation of Myeloproliferative Neoplasms

Hematol Oncol Clin North Am. 2021 Apr;35(2):237-251. doi: 10.1016/j.hoc.2021.01.001. Epub 2021 Feb 5.

Abstract

This article reviews the genetic data on epigenetic modifying mutations in myeloproliferative neoplasms and their clinical implications, preclinical studies exploring our current understanding of how mutations in epigenetic modifying proteins cooperate with myeloproliferative neoplasms drivers to promote disease progression, and recent advances in novel therapeutics supporting the role of targeting epigenetic pathways to treat fibrotic progression.

Keywords: Epigenetic pathways; Epigenetics of MPN; Fibrotic progression; Myelofibrosis; Myeloproliferative neoplasms; Preclinical studies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Disease Progression
  • Epigenesis, Genetic*
  • Fibrosis
  • Humans
  • Mutation
  • Myeloproliferative Disorders* / genetics
  • Neoplasms* / genetics