Hydroxychloroquine modulates immunological pathways activated by RNA:DNA hybrids in Aicardi-Goutières syndrome patients carrying RNASEH2 mutations

Cell Mol Immunol. 2021 Jun;18(6):1593-1595. doi: 10.1038/s41423-021-00657-0. Epub 2021 Mar 11.

Jessica Garau^#¹, Daisy Sproviero^#¹, Francesca Dragoni^{1

2}, Elisa Piscianz³, Carolina Santonicola², Davide Tonduti⁴, Stephana Carelli^{5

6}, Alessandra Tesser⁷, Gian Vincenzo Zuccotti^{5

6

8}, Alberto Tommasini^{3

7}, Simona Orcesi^{9

10}, Orietta Pansarasa¹¹, Cristina Cereda¹

¹ Genomic and post-Genomic Unit, IRCCS Mondino Foundation, Pavia, Italy.
² Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
³ Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
⁴ Child Neurology Unit - COALA (Center for diagnosis and treatment of leukodystrophies) - Children's Hospital "V. Buzzi", Milan, Italy.
⁵ Department of Biomedical and Clinical Sciences "L. Sacco", University of Milan, Milan, Italy.
⁶ Pediatric Clinical Research Center Fondazione Romeo ed Enrica Invernizzi, University of Milan, Milan, Italy.
⁷ Department of Pediatrics, Institute for Maternal and Child Health, "IRCCS Burlo Garofolo", Trieste, Italy.
⁸ Department of Pediatrics, Children's Hospital "V. Buzzi", Milan, Italy.
⁹ Unit of Child Neurology and Psychiatry, IRCCS Mondino Foundation, Pavia, Italy.
¹⁰ Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
¹¹ Genomic and post-Genomic Unit, IRCCS Mondino Foundation, Pavia, Italy. orietta.pansarasa@mondino.it.

^# Contributed equally.

No abstract available

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