Cerebral Blood Flow in Chronic Kidney Disease

Bernard Choi; Christian Crouzet; Wei Ling Lau; David H Cribbs; Mark J Fisher

doi:10.1016/j.jstrokecerebrovasdis.2021.105702

Cerebral Blood Flow in Chronic Kidney Disease

J Stroke Cerebrovasc Dis. 2021 Sep;30(9):105702. doi: 10.1016/j.jstrokecerebrovasdis.2021.105702. Epub 2021 Mar 11.

Authors

Bernard Choi¹, Christian Crouzet², Wei Ling Lau³, David H Cribbs⁴, Mark J Fisher⁵

Affiliations

¹ Departments of Biomedical Engineering and Surgery, University of California, Irvine, CA, United States; Beckman Laser Institute and Medical Clinic, University of California, 1002 Health Sciences Road East, Irvine, CA 92612, United States; Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, CA, United States. Electronic address: choib@uci.edu.
² Beckman Laser Institute and Medical Clinic, University of California, 1002 Health Sciences Road East, Irvine, CA 92612, United States; Department of Biomedical Engineering, University of California, Irvine, CA, United States. Electronic address: ccrouzet@uci.edu.
³ Division of Nephrology, Department of Medicine, University of California, Orange, CA, United States. Electronic address: wllau@hs.uci.edu.
⁴ Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, United States. Electronic address: cribbs@uci.edu.
⁵ Beckman Laser Institute and Medical Clinic, University of California, 1002 Health Sciences Road East, Irvine, CA 92612, United States; Department of Neurology, University of California Irvine, Orange, CA, United States. Electronic address: mfisher@hs.uci.edu.

PMID: 33714675
PMCID: PMC8384649
DOI: 10.1016/j.jstrokecerebrovasdis.2021.105702

Abstract

The prevalence of mild cognitive impairment increases with age and is further exacerbated by chronic kidney disease (CKD). CKD is associated with (1) mild cognitive impairment, (2) impaired endothelial function, (3) impaired blood-brain barrier, (4) increased cerebral microhemorrhage burden, (5) increased cerebral blood flow (CBF), (6) impaired cerebral autoregulation, (7) impaired cerebrovascular reactivity, and (8) increased arterial stiffness. We report preliminary findings from our group that demonstrate altered cerebrovascular reactivity in a mouse model of CKD-associated vascular calcification. The CBF of CKD mice increased more quickly in response to hypercapnia (p < 0.05) but then decreased prematurely during hypercapnia challenge (p < 0.05). Together, these results indicate that altered kidney function can lead to alterations in the cerebral microvasculature, and hence brain health.

Keywords: Cerebral blood flow; Chronic kidney disease; Laser speckle contrast imaging; Speckle contrast; Vascular dysfunction; Vasomotor reactivity.

Publication types

Review

MeSH terms

Animals
Cerebral Arteries / physiopathology*
Cerebrovascular Circulation*
Cerebrovascular Disorders / etiology*
Cerebrovascular Disorders / physiopathology
Cognition
Cognitive Dysfunction / etiology
Cognitive Dysfunction / physiopathology
Cognitive Dysfunction / psychology
Disease Models, Animal
Female
Homeostasis
Humans
Hypercapnia / complications
Hypercapnia / physiopathology
Kidney / physiopathology*
Mice
Mice, Inbred DBA
Microcirculation
Renal Insufficiency, Chronic / complications*
Renal Insufficiency, Chronic / physiopathology

Abstract

Publication types

MeSH terms

Grants and funding