Disruption of the NOX5 Gene Aggravates Atherosclerosis in Rabbits

Circ Res. 2021 Apr 30;128(9):1320-1322. doi: 10.1161/CIRCRESAHA.120.318611. Epub 2021 Mar 17.

Authors

Gábor L Petheő^#^{1

2}, Andrea Kerekes^#³, Máté Mihálffy^{1

2}, Ágnes Donkó^{1

2}, Lilla Bodrogi³, Gabriella Skoda³, Mónika Baráth^{1

2}, Orsolya Ivett Hoffmann³, Zsolt Szeles^{1

2}, Bernadett Balázs¹, Gábor Sirokmány¹, Júlia R Fábián^{1

2}, Zsuzsanna E Tóth⁴, Ivett Baksa⁵, Imre Kacskovics⁵, László Hunyady^{1

6}, László Hiripi³, Zsuzsanna Bősze³, Miklós Geiszt^{1

2}

Affiliations

¹ Department of Physiology G.L.P., M.M., A.D., M.B., Z.S., B.B., G.S., J.R.F., L. Hunyady, M.G.).
² "Momentum" Peroxidase Enzyme Research Group of the Semmelweis University (G.L.P., M.M., A.D., M.B., Z.S., B.B., G.S., J.R.F., M.G.).
³ NARIC-Agricultural Biotechnology Institute, Animal Biotechnology Department, Gödöllő, Hungary (A.K., L.B., G.S., O.I.H., L. Hiripi, Z.B.).
⁴ Department of Anatomy, Histology and Embryology (Z.E.T.), Faculty of Medicine Semmelweis University, Budapest, Hungary.
⁵ ImmunoGenes Ltd, Budakeszi, Hungary (I.B., I.K.).
⁶ MTA-SE Laboratory of Molecular Physiology, Budapest, Hungary (L. Hunyady).

^# Contributed equally.

PMID: 33726501
DOI: 10.1161/CIRCRESAHA.120.318611

No abstract available

Keywords: NADPH oxidase 5; atherosclerosis; blood vessels; rabbits; reactive oxygen species.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Acetylcholine / pharmacology
Animals
Aorta, Thoracic / drug effects
Atherosclerosis / genetics*
Clustered Regularly Interspaced Short Palindromic Repeats
Diet, Atherogenic
Epinephrine / pharmacology
Male
NADPH Oxidase 5 / deficiency
NADPH Oxidase 5 / genetics*
Plaque, Atherosclerotic / genetics
Plaque, Atherosclerotic / pathology
Potassium / pharmacology
Rabbits

Substances

NADPH Oxidase 5
Acetylcholine
Potassium
Epinephrine