Keep it focused: PRMT6 drives the localization of RCC1 to chromosomes to facilitate mitosis, cell proliferation, and tumorigenesis

Mol Cell. 2021 Mar 18;81(6):1128-1129. doi: 10.1016/j.molcel.2021.02.026.

Abstract

Huang et al. (2021) identified a mechanism acting through the arginine methyltransferase PRMT6 that stabilizes the interaction of RCC1 with chromatin, promoting cell proliferation and tumorigenicity. Targeting this mechanism might enhance the treatment of tumors such as glioblastoma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Carcinogenesis / genetics
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism
  • Cell Proliferation
  • Chromosomes / metabolism
  • Glioblastoma*
  • Guanine Nucleotide Exchange Factors / metabolism
  • Humans
  • Methylation
  • Mitosis
  • Nuclear Proteins* / genetics
  • Nuclear Proteins* / metabolism
  • Protein-Arginine N-Methyltransferases / genetics
  • Protein-Arginine N-Methyltransferases / metabolism
  • Stem Cells / metabolism

Substances

  • Cell Cycle Proteins
  • Guanine Nucleotide Exchange Factors
  • Nuclear Proteins
  • RCC1 protein, human
  • PRMT6 protein, human
  • Protein-Arginine N-Methyltransferases