Abstract
Huang et al. (2021) identified a mechanism acting through the arginine methyltransferase PRMT6 that stabilizes the interaction of RCC1 with chromatin, promoting cell proliferation and tumorigenicity. Targeting this mechanism might enhance the treatment of tumors such as glioblastoma.
Copyright © 2021 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Carcinogenesis / genetics
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / metabolism
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Cell Proliferation
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Chromosomes / metabolism
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Glioblastoma*
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Guanine Nucleotide Exchange Factors / metabolism
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Humans
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Methylation
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Mitosis
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Nuclear Proteins* / genetics
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Nuclear Proteins* / metabolism
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Protein-Arginine N-Methyltransferases / genetics
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Protein-Arginine N-Methyltransferases / metabolism
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Stem Cells / metabolism
Substances
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Cell Cycle Proteins
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Guanine Nucleotide Exchange Factors
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Nuclear Proteins
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RCC1 protein, human
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PRMT6 protein, human
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Protein-Arginine N-Methyltransferases