Engaging the front wheels to drive through fibrous terrain

Florian Gaertner; Michael Sixt

doi:10.1016/j.devcel.2021.03.002

Engaging the front wheels to drive through fibrous terrain

Dev Cell. 2021 Mar 22;56(6):723-725. doi: 10.1016/j.devcel.2021.03.002.

Authors

Florian Gaertner¹, Michael Sixt²

Affiliations

¹ Institute of Science and Technology Austria (IST Austria), 3400 Klosterneuburg, Austria. Electronic address: florian.gaertner@ist.ac.at.
² Institute of Science and Technology Austria (IST Austria), 3400 Klosterneuburg, Austria. Electronic address: michael.sixt@ist.ac.at.

PMID: 33756118
DOI: 10.1016/j.devcel.2021.03.002

Abstract

In this issue of Developmental Cell, Doyle and colleagues identify periodic anterior contraction as a characteristic feature of fibroblasts and mesenchymal cancer cells embedded in 3D collagen gels. This contractile mechanism generates a matrix prestrain required for crawling in fibrous 3D environments.

Publication types

Comment

MeSH terms

Collagen*
Fibroblasts*
Gels
Humans

Substances

Gels
Collagen