Metabolic Vulnerabilities in Brain Cancer

Danielle Morrow; Jenna Minami; David A Nathanson

doi:10.1016/j.nec.2020.12.006

Metabolic Vulnerabilities in Brain Cancer

Neurosurg Clin N Am. 2021 Apr;32(2):159-169. doi: 10.1016/j.nec.2020.12.006.

Authors

Danielle Morrow¹, Jenna Minami¹, David A Nathanson²

Affiliations

¹ Department of Molecular and Medical Pharmacology, University of California Los Angeles.
² Department of Molecular and Medical Pharmacology, University of California Los Angeles; David Geffen School of Medicine, University of California Los Angeles. Electronic address: dnathanson@mednet.ucla.edu.

PMID: 33781499
DOI: 10.1016/j.nec.2020.12.006

Abstract

Glioblastomas (GBMs) exhibit altered metabolism to support a variety of bioenergetic and biosynthetic demands for tumor growth, invasion, and drug resistance. Changes in glycolytic flux, oxidative phosphorylation, the pentose phosphate pathway, fatty acid biosynthesis and oxidation, and nucleic acid biosynthesis are observed in GBMs to help drive tumorigenesis. Both the genetic landscape of GBMs and the unique brain tumor microenvironment shape metabolism; therefore, an understanding of how both intrinsic and extrinsic factors modulate metabolism is becoming increasingly important for finding effect targets and therapeutics for GBM.

Keywords: GBM; Metabolism; Oncogene; Tumor microenvironment.

Publication types

Review

MeSH terms

Brain Neoplasms* / drug therapy
Brain Neoplasms* / genetics
Glioblastoma* / drug therapy
Glioblastoma* / genetics
Glycolysis
Humans
Tumor Microenvironment

Abstract

Publication types

MeSH terms

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