The Role of the Interplay Between Autophagy and NLRP3 Inflammasome in Metabolic Disorders

Shuangyu Lv; Honggang Wang; Xiaotian Li

doi:10.3389/fcell.2021.634118

The Role of the Interplay Between Autophagy and NLRP3 Inflammasome in Metabolic Disorders

Front Cell Dev Biol. 2021 Mar 16:9:634118. doi: 10.3389/fcell.2021.634118. eCollection 2021.

Authors

Shuangyu Lv¹, Honggang Wang¹, Xiaotian Li¹

Affiliation

¹ Institute of Biomedical Informatics, Bioinformatics Center, School of Basic Medical Sciences, Henan University, Kaifeng, China.

Abstract

Autophagy is an important and conserved cellular pathway in which cells transmit cytoplasmic contents to lysosomes for degradation. It plays an important role in maintaining the balance of cell composition synthesis, decomposition and reuse, and participates in a variety of physiological and pathological processes. The nucleotide-binding oligomerization domain-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome can induce the maturation and secretion of Interleukin-1 beta (IL-1β) and IL-18 by activating caspase-1. It is involved in many diseases. In recent years, the interplay between autophagy and NLRP3 inflammasome has been reported to contribute to many diseases including metabolic disorders related diseases. In this review, we summarized the recent studies on the interplay between autophagy and NLRP3 inflammasome in metabolic disorders to provide ideas for the relevant basic research in the future.

Keywords: NLRP3 inflammasome; autophagy; glucose metabolic disorders; inflammation-related metabolic disorders; uric acid metabolic disorders.

Publication types

Review