Empowering MYC carcinogenesis via RNA loops

Mol Cell. 2021 Apr 1;81(7):1365-1367. doi: 10.1016/j.molcel.2021.03.011.

Abstract

Cieśla et al. (2021) uncover intricate circuits of post-transcriptional regulation induced by the Myc oncogene, including alternative splicing and translational control, which are relevant for breast cancer prognosis and contribute to metabolic reprogramming and stem cell-like features of cancer cells.

Publication types

  • Comment

MeSH terms

  • Breast Neoplasms*
  • Carcinogenesis / genetics
  • Humans
  • Power, Psychological
  • Proto-Oncogene Proteins c-myc / genetics
  • RNA
  • Spliceosomes

Substances

  • Proto-Oncogene Proteins c-myc
  • RNA