Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH

Daniel M Ramos; William C Skarnes; Andrew B Singleton; Mark R Cookson; Michael E Ward

doi:10.1016/j.neuron.2021.03.022

Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH

Neuron. 2021 Apr 7;109(7):1080-1083. doi: 10.1016/j.neuron.2021.03.022.

Authors

Daniel M Ramos¹, William C Skarnes², Andrew B Singleton³, Mark R Cookson⁴, Michael E Ward⁵

Affiliations

¹ Center for Alzheimer's Disease and Related Dementias, National Institutes of Health, Bethesda, MD, USA.
² The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
³ Center for Alzheimer's Disease and Related Dementias, National Institutes of Health, Bethesda, MD, USA; Lab of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
⁴ Center for Alzheimer's Disease and Related Dementias, National Institutes of Health, Bethesda, MD, USA; Lab of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. Electronic address: cookson@mail.nih.gov.
⁵ Center for Alzheimer's Disease and Related Dementias, National Institutes of Health, Bethesda, MD, USA; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. Electronic address: wardme@nih.gov.

Abstract

The iPSC Neurodegenerative Disease Initiative (iNDI) is the largest-ever iPSC genome engineering project. iNDI will model more than 100 mutations associated with Alzheimer's disease and related dementias (ADRD) in isogenic iPSC lines. Resulting cell lines and phenotypic datasets will be broadly shared.

Published by Elsevier Inc.

Publication types

Research Support, N.I.H., Intramural

MeSH terms

Alzheimer Disease / therapy
Genetic Engineering / methods*
Humans
Induced Pluripotent Stem Cells / transplantation
Neural Stem Cells / transplantation
Neurodegenerative Diseases / genetics*
Neurodegenerative Diseases / therapy*
Stem Cell Research*
Stem Cell Transplantation*

Grants and funding

ZIA AG000535/ImNIH/Intramural NIH HHS/United States