Renal Squamous Cell Carcinoma-related Polymyositis in a Patient with Autosomal Dominant Polycystic Kidney Disease

Intern Med. 2021;60(8):1237-1242. doi: 10.2169/internalmedicine.5375-20. Epub 2021 Apr 15.

Abstract

A 74-year-old Japanese woman diagnosed with autosomal dominant polycystic kidney disease (ADPKD) was admitted to our institute for the further examination of right-side groin pain developing in the past week. The patient was diagnosed with polymyositis (PM). Diagnostic imaging showed a mass lesion measuring 8 cm and a renal stone in the right kidney. Immediately following surgical resection of the right kidney, the patient's serum CK decreased to the normal range. A histopathological analysis showed well-differentiated squamous cell carcinoma. In conclusion, this case showed a close relationship between the occurrence of squamous cell carcinoma and the development of PM in an ADPKD patient.

Keywords: autosomal dominant polycystic kidney disease; paraneoplastic syndrome; polymyositis; renal pelvis cancer; squamous cell carcinoma; squamous metaplasia.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Carcinoma, Squamous Cell* / complications
  • Carcinoma, Squamous Cell* / diagnosis
  • Carcinoma, Squamous Cell* / surgery
  • Female
  • Humans
  • Kidney
  • Kidney Neoplasms*
  • Polycystic Kidney, Autosomal Dominant* / complications
  • Polycystic Kidney, Autosomal Dominant* / diagnosis
  • Polymyositis* / complications
  • Polymyositis* / diagnosis