Internalized Activation of Membrane Receptors: From Phenomenon to Theory

Wenjing Wang; Jingwei Bian; Zijian Li

doi:10.1016/j.tcb.2021.03.008

Internalized Activation of Membrane Receptors: From Phenomenon to Theory

Trends Cell Biol. 2021 Jun;31(6):428-431. doi: 10.1016/j.tcb.2021.03.008. Epub 2021 Apr 12.

Authors

Wenjing Wang¹, Jingwei Bian¹, Zijian Li²

Affiliations

¹ Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, 100191, China; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, 100191, China; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing, 100191, China; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, 100191, China.
² Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, 100191, China; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, 100191, China; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing, 100191, China; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, 100191, China. Electronic address: lizijian@bjmu.edu.cn.

PMID: 33858767
DOI: 10.1016/j.tcb.2021.03.008

Abstract

Many studies over the past decade have reported that internalized membrane receptors can trigger distinct signal activation, rather than being desensitized inside the cell. Here, we propose the concept of 'internalized activation' as a distinctive component of the receptor theory framework and exhibit its significance and role in diseases.

Keywords: internalized activation; receptor activation; receptor internalization; signaling.

Publication types

Research Support, Non-U.S. Gov't