Comment on "Circadian rhythms in the absence of the clock gene Bmal1"

Elan Ness-Cohn; Ravi Allada; Rosemary Braun

doi:10.1126/science.abe9230

Comment on "Circadian rhythms in the absence of the clock gene Bmal1"

Science. 2021 Apr 16;372(6539):eabe9230. doi: 10.1126/science.abe9230.

Authors

Elan Ness-Cohn^{1

2}, Ravi Allada^{2

3}, Rosemary Braun^{4

2

5

6}

Affiliations

¹ Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
² NSF-Simons Center for Quantitative Biology, Northwestern University, Evanston, IL 60208, USA.
³ Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA.
⁴ Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA. rbraun@northwestern.edu.
⁵ Department of Physics and Astronomy, Northwestern University, Evanston, IL 60208, USA.
⁶ Department of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, IL 60208, USA.

Abstract

Ray et al (Reports, 14 February 2020, p. 800) report apparent transcriptional circadian rhythms in mouse tissues lacking the core clock component BMAL1. To better understand these surprising results, we reanalyzed the associated data. We were unable to reproduce the original findings, nor could we identify reliably cycling genes. We conclude that there is insufficient evidence to support circadian transcriptional rhythms in the absence of Bmal1.

Publication types

Comment

MeSH terms

ARNTL Transcription Factors* / genetics
Animals
Circadian Rhythm* / genetics
Mice

Substances

ARNTL Transcription Factors

Abstract

Publication types

MeSH terms

Substances

Grants and funding