Structure of Rad5 provides insights into its role in tolerance to replication stress

Miaomiao Shen; Nalini Dhingra; Quan Wang; Xiaoxin Gong; Xin Xu; Hengyao Niu; Xiaolan Zhao; Song Xiang

doi:10.1080/23723556.2021.1889348

Structure of Rad5 provides insights into its role in tolerance to replication stress

Mol Cell Oncol. 2021 Mar 4;8(2):1889348. doi: 10.1080/23723556.2021.1889348. eCollection 2021.

Authors

Miaomiao Shen¹, Nalini Dhingra², Quan Wang³, Xiaoxin Gong¹, Xin Xu¹, Hengyao Niu³, Xiaolan Zhao², Song Xiang¹

Affiliations

¹ Department of Biochemistry and Molecular Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), the Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, Tianjin, P. R. China.
² Molecular Biology Department, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
³ Department of Molecular and Cellular Biochemistry, Indiana University Bloomington, IN, USA.

Abstract

The Rad5 family of proteins are critical genome maintenance factors, with helicase-like transcription factor (HLTF) and SNF2 histone linker PHD RING helicase (SHRPH) in humans implicated in several types of cancer. How their multiple activities coordinate has been unclear. Our recent study on Rad5 shed light on this question.

Keywords: HIRAN domain; HLTF; Rad5; Replication stress; protein structure.

Grants and funding

P30 CA008748/CA/NCI NIH HHS/United States