RETRACTED: Pancreatic cancer cells-derived exosomal long non-coding RNA CCAT1/microRNA-138-5p/HMGA1 axis promotes tumor angiogenesis

Life Sci. 2021 Aug 1:278:119495. doi: 10.1016/j.lfs.2021.119495. Epub 2021 Apr 16.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. Concern was raised about the reliability of the Western blot results in Figs. 2B and 5I+J, which appear to have the same eyebrow shaped phenotype as many other publications tabulated here (https://docs.google.com/spreadsheets/d/149EjFXVxpwkBXYJOnOHb6RhAqT4a2llhj9LM60MBffM/edit#gid=0). In addition, Fig. 4B appears to show a digital composition of xenografted tumors. The journal requested the corresponding author comment on these concerns and provide the raw data. However the authors were not able to satisfactorily fulfil this request and therefore the Editor-in-Chief decided to retract the article.

Keywords: Angiogenesis; Exosomes; High mobility group A1; Human microvascular endothelial cells; Long non-coding RNA colon cancer-associated transcript-1; MicroRNA-138-5p; Pancreatic cancer.

Publication types

  • Retracted Publication

MeSH terms

  • Adult
  • Aged
  • Animals
  • Apoptosis
  • Cell Line, Tumor
  • Cell Proliferation
  • Coculture Techniques
  • Collagen / chemistry
  • Drug Combinations
  • Exosomes / metabolism*
  • Female
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • HMGA1a Protein / metabolism*
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Laminin / chemistry
  • Male
  • Mice
  • Mice, Nude
  • MicroRNAs / metabolism*
  • Middle Aged
  • Neoplasm Transplantation
  • Neovascularization, Pathologic*
  • Pancreatic Neoplasms / genetics
  • Pancreatic Neoplasms / metabolism*
  • Proteoglycans / chemistry
  • RNA, Long Noncoding / genetics*

Substances

  • CCAT1 long noncoding RNA, human
  • Drug Combinations
  • HMGA1 protein, human
  • Laminin
  • MIRN138 microRNA, human
  • MicroRNAs
  • Proteoglycans
  • RNA, Long Noncoding
  • matrigel
  • HMGA1a Protein
  • Collagen