Evolving barcodes shed light into evolving metastases

Yibin Kang; Charlotte Kuperwasser

doi:10.1016/j.devcel.2021.03.029

Evolving barcodes shed light into evolving metastases

Dev Cell. 2021 Apr 19;56(8):1077-1079. doi: 10.1016/j.devcel.2021.03.029.

Authors

Yibin Kang¹, Charlotte Kuperwasser²

Affiliations

¹ Department of Molecular Biology, Princeton University, Princeton, NJ, USA; Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA. Electronic address: ykang@princeton.edu.
² Department of Developmental, Chemical & Molecular Biology, Tufts University, Boston, MA 02111, USA; Laboratory for the Convergence of Biomedical, Physical, and Engineering Sciences, Tufts University School of Medicine, Boston, MA 02111, USA. Electronic address: charlotte.kuperwasser@tufts.edu.

PMID: 33878297
DOI: 10.1016/j.devcel.2021.03.029

Abstract

Selective pressure and signals from the tissue microenvironment drive metastasis and determine the survival of metastatic tumor cells at distant organs. Zhang et al. and Bado et al. apply CRISPR-mediated evolving barcode technology to elucidate the role of the bone microenvironment in the evolution of breast cancer metastasis.

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MeSH terms

Bone and Bones
Breast Neoplasms*
Female
Humans
Tumor Microenvironment*