CaMKII Serine 280 O-GlcNAcylation Links Diabetic Hyperglycemia to Proarrhythmia

Circ Res. 2021 Jun 25;129(1):98-113. doi: 10.1161/CIRCRESAHA.120.318402. Epub 2021 Apr 30.

Abstract

[Figure: see text].

Keywords: acetylglucosamine; action potential; electrophysiology; hyperglycemia; phosphorylation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials
  • Adult
  • Aged
  • Animals
  • Arrhythmias, Cardiac / enzymology*
  • Arrhythmias, Cardiac / genetics
  • Arrhythmias, Cardiac / physiopathology
  • Biomarkers / blood
  • Blood Glucose / metabolism*
  • Calcium Signaling*
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2 / genetics
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism*
  • Case-Control Studies
  • Diabetes Mellitus, Experimental / blood
  • Diabetes Mellitus, Experimental / enzymology*
  • Diabetes Mellitus, Experimental / genetics
  • Excitation Contraction Coupling
  • Female
  • Glycosylation
  • Heart Rate
  • Humans
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred ICR
  • Mice, Transgenic
  • Middle Aged
  • Mutation
  • Myocardial Contraction
  • Myocytes, Cardiac / enzymology*
  • NADPH Oxidase 2 / genetics
  • NADPH Oxidase 2 / metabolism
  • Phosphorylation
  • Protein Processing, Post-Translational*

Substances

  • Biomarkers
  • Blood Glucose
  • Cybb protein, mouse
  • NADPH Oxidase 2
  • CAMK2G protein, human
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2
  • Camk2g protein, mouse