Unfolding New Roles for Guanine-Based Purines and Their Metabolizing Enzymes in Cancer and Aging Disorders

Front Pharmacol. 2021 Apr 16:12:653549. doi: 10.3389/fphar.2021.653549. eCollection 2021.

P Di Iorio^{1

2}, S Beggiato^{1

2}, M Ronci^{2

3}, C B Nedel⁴, C I Tasca⁵, M Zuccarini^{1

2}

¹ Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy.
² Center for Advanced Studies and Technologies (CAST), University of Chieti-Pescara, Chieti, Italy.
³ Department of Pharmacy, University G. D'Annunzio Chieti, Chieti, Italy.
⁴ Laboratório de Biologia Celular de Gliomas, Programa de Pós-Graduação Em Biologia Celular e Do Desenvolvimento, Universidade Federal de Santa Catarina, Florianópolis, Brazil.
⁵ Laboratório de Neuroquímica-4, Programa de Pós-Graduação Em Bioquímica, Universidade Federal de Santa Catarina, Florianópolis, Brazil.

No abstract available

Keywords: aging disease; cancer; guanine deaminase; guanine-based purines; purine nucleoside phosphorylase; reactive oxygen species.