ATG4: More Than a Protease?

Robin Ketteler; Sharon A Tooze

doi:10.1016/j.tcb.2021.04.003

ATG4: More Than a Protease?

Trends Cell Biol. 2021 Jul;31(7):515-516. doi: 10.1016/j.tcb.2021.04.003. Epub 2021 May 7.

Authors

Robin Ketteler¹, Sharon A Tooze²

Affiliations

¹ MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.
² The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address: Sharon.tooze@crick.ac.uk.

PMID: 33972154
DOI: 10.1016/j.tcb.2021.04.003

Abstract

The ATG4 proteases are key regulators of autophagy. Until recently it was thought that their main function was to mediate the processing of ATG8 family members. A new study by Nguyen et al. reveals a role for ATG4s, independent of their catalytic activity, and proposes novel functions in mediating lipid transfer and mitophagy.

Keywords: ARFIP2; ATG9A; GABARAP; LC3; autophagy; mitophagy.

MeSH terms

Autophagy
Autophagy-Related Protein 8 Family
Autophagy-Related Proteins / genetics
Humans
Microtubule-Associated Proteins*
Peptide Hydrolases*

Substances

Autophagy-Related Protein 8 Family
Autophagy-Related Proteins
Microtubule-Associated Proteins
Peptide Hydrolases

Grants and funding

MC_EX_G0800785/MRC_/Medical Research Council/United Kingdom