Lysosomes to the rescue: Anterograde axonal lysosome transport and neuronal proteostasis

Chan Choo Yap; Bettina Winckler

doi:10.1016/j.devcel.2021.04.024

Lysosomes to the rescue: Anterograde axonal lysosome transport and neuronal proteostasis

Dev Cell. 2021 May 17;56(10):1361-1362. doi: 10.1016/j.devcel.2021.04.024.

Authors

Chan Choo Yap¹, Bettina Winckler²

Affiliations

¹ Department of Cell Biology, University of Virginia, 1340 Jefferson Park Avenue, Pinn Hall Room 3226, Charlottesville, VA 22908, USA. Electronic address: cy5x@virginia.edu.
² Department of Cell Biology, University of Virginia, 1340 Jefferson Park Avenue, Pinn Hall Room 3226, Charlottesville, VA 22908, USA. Electronic address: bw5h@virginia.edu.

PMID: 34004149
DOI: 10.1016/j.devcel.2021.04.024

Abstract

Niemann-Pick is a lysosomal storage disease caused by loss of the lysosomal cholesterol exporter NPC1 and leads to axon degeneration. Roney et al. report that immature autophagosomes accumulate in axons because cholesterol-laden lysosomes in the soma are not transported to the axon for autophagosome fusion and maturation because they aberrantly sequester non-functioning kinesin-1.

Publication types

Comment

MeSH terms

Autophagosomes / metabolism
Axonal Transport
Lysosomes* / metabolism
Neurons
Proteostasis*