Emerging concepts in PD-1 checkpoint biology

Semin Immunol. 2021 Feb:52:101480. doi: 10.1016/j.smim.2021.101480. Epub 2021 May 15.

Abstract

The PD-1 pathway is a cornerstone in immune regulation. While the PD-1 pathway has received considerable attention for its role in contributing to the maintenance of T cell exhaustion in chronic infection and cancer, the PD-1 pathway plays diverse roles in regulating host immunity beyond T cell exhaustion. Here, we discuss emerging concepts in the PD-1 pathway, including (1) the impact of PD-1 inhibitors on diverse T cell differentiation states including effector and memory T cell development during acute infection, as well as T cell exhaustion during chronic infection and cancer, (2) the role of PD-1 in regulating Treg cells, NK cells, and ILCs, and (3) the functions of PD-L1/B7-1 and PD-L2/RGMb/neogenin interactions. We then discuss the emerging use of neoadjuvant PD-1 blockade in the treatment of early-stage cancers and how the timing of PD-1 blockade may improve clinical outcomes. The diverse binding partners of PD-1 and its associated ligands, broad expression patterns of the receptors and ligands, differential impact of PD-1 modulation on cells depending on location and state of differentiation, and timing of PD-1 blockade add additional layers of complexity to the PD-1 pathway, and are important considerations for improving the efficacy and safety of PD-1 pathway therapeutics.

Keywords: Cancer immunotherapy; Immune regulation; Neoadjuvant; PD-1 pathway; T cell exhaustion.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Immune Checkpoint Inhibitors / therapeutic use*
  • Killer Cells, Natural
  • Lymphocyte Activation
  • Neoplasms* / therapy
  • Programmed Cell Death 1 Receptor / antagonists & inhibitors*

Substances

  • Immune Checkpoint Inhibitors
  • Programmed Cell Death 1 Receptor