Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci

Circ Res. 2021 Jul 9;129(2):240-258. doi: 10.1161/CIRCRESAHA.121.318971. Epub 2021 May 24.

Authors

Affiliations

¹ A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio (T.Ö., K.Õ., V.N., A.T., I.S., E.A., S.Y.-H., M.U.K.).
² Department of Cellular and Molecular Medicine, The College of Medicine, The University of Arizona, Tucson, AZ (L.K.S., C.E.R.).
³ Center for Public Health Genomics (R.A., M.C.), University of Virginia, Charlottesville.
⁴ Turku Bioscience Centre, University of Turku and Åbo Akademi University, Finland (T.L.).
⁵ Department of Biomedical Engineering (M.C.), University of Virginia, Charlottesville.

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: atherosclerosis; coronary artery disease; genetics; genome-wide association study; myocardial infarction.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Cells, Cultured
Chromatin Immunoprecipitation Sequencing
Coronary Artery Disease / genetics*
Coronary Artery Disease / metabolism
Coronary Artery Disease / pathology
DNA Methylation*
Endothelial Cells / metabolism*
Endothelial Cells / pathology
Epigenesis, Genetic*
Epigenome*
Epigenomics*
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Lymphocytes / metabolism
Lymphocytes / pathology
Macrophages / metabolism
Macrophages / pathology
Male
Middle Aged
Myocytes, Smooth Muscle / metabolism*
Myocytes, Smooth Muscle / pathology
Phenotype
Plaque, Atherosclerotic*
Polymorphism, Single Nucleotide
Quantitative Trait Loci
RNA-Seq
Single-Cell Analysis*

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