Implications of mRNA translation dysregulation for neurological disorders

Aya Jishi; Xin Qi; Helen C Miranda

doi:10.1016/j.semcdb.2020.09.005

Implications of mRNA translation dysregulation for neurological disorders

Semin Cell Dev Biol. 2021 Jun:114:11-19. doi: 10.1016/j.semcdb.2020.09.005. Epub 2020 Oct 21.

Authors

Aya Jishi¹, Xin Qi¹, Helen C Miranda²

Affiliations

¹ Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
² Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA; Department of Neurosciences, School of Medicine Case Western Reserve University, Cleveland, OH, USA. Electronic address: helen.miranda@case.edu.

Abstract

The translation of information encoded in the DNA into functional proteins is one of the tenets of cellular biology. Cell survival and function depend on the tightly controlled processes of transcription and translation. Growing evidence suggests that dysregulation in mRNA translation plays an important role in the pathogenesis of several neurodevelopmental diseases, such as autism spectrum disorder (ASD) and fragile X syndrome (FXS) as well as neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS). In this review, we provide an overview of mRNA translation and its modes of regulation that have been implicated in neurological disease.

Keywords: AD; ALS; ASD; FXS; Neurodegeneration; Neurodevelopment; PD; Translational dysregulation; mRNA processing.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Mice
Nervous System Diseases / genetics*
RNA, Messenger / genetics*

Substances

RNA, Messenger

Abstract

Publication types

MeSH terms

Substances

Grants and funding