Macrophage-tumor cell intertwine drives the transition into a mesenchymal-like cellular state of glioblastoma

Zhihong Chen; Dolores Hambardzumyan

doi:10.1016/j.ccell.2021.05.003

Macrophage-tumor cell intertwine drives the transition into a mesenchymal-like cellular state of glioblastoma

Cancer Cell. 2021 Jun 14;39(6):743-745. doi: 10.1016/j.ccell.2021.05.003. Epub 2021 Jun 3.

Authors

Zhihong Chen¹, Dolores Hambardzumyan²

Affiliations

¹ Department of Oncological Sciences, The Tisch Cancer Institute, Mount Sinai Icahn School of Medicine, New York City, NY, USA.
² Department of Oncological Sciences, The Tisch Cancer Institute, Mount Sinai Icahn School of Medicine, New York City, NY, USA; Department of Neurosurgery, Mount Sinai Icahn School of Medicine, New York City, NY, USA. Electronic address: dolores.hambardzumyan@mssm.edu.

PMID: 34087163
DOI: 10.1016/j.ccell.2021.05.003

Abstract

Macrophages are the major non-neoplastic infiltrates in the glioblastoma microenvironment. In this issue of Cancer Cell, Hara et al. (2021) demonstrate that macrophages induce a transition of glioblastoma cells into the mesenchymal-like cellular state associated with an increased mesenchymal program in macrophages themselves and enhanced cytotoxicity of T cells.

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MeSH terms

Epithelial-Mesenchymal Transition
Gene Expression Regulation, Neoplastic
Glioblastoma* / genetics
Humans
Macrophages
Neoplastic Stem Cells
Tumor Microenvironment