Association of Apparent Treatment-Resistant Hypertension With Differential Risk of End-Stage Kidney Disease Across Racial Groups in the Million Veteran Program

Elvis A Akwo; Cassianne Robinson-Cohen; Cecilia P Chung; Shailja C Shah; Nancy J Brown; T Alp Ikizler; Otis D Wilson; Bryce X Rowan; Megan M Shuey; Edward D Siew; James M Luther; Ayush Giri; Jacklyn N Hellwege; Digna R Velez Edwards; Christianne L Roumie; Ran Tao; Phil S Tsao; J Michael Gaziano; Peter W F Wilson; Christopher J O'Donnell; Todd L Edwards; Csaba P Kovesdy; Adriana M Hung; VA Million Veteran Program

doi:10.1161/HYPERTENSIONAHA.120.16181

Association of Apparent Treatment-Resistant Hypertension With Differential Risk of End-Stage Kidney Disease Across Racial Groups in the Million Veteran Program

Hypertension. 2021 Aug;78(2):376-386. doi: 10.1161/HYPERTENSIONAHA.120.16181. Epub 2021 Jun 21.

Authors

Elvis A Akwo^{1

2

3}, Cassianne Robinson-Cohen^{1

2

3}, Cecilia P Chung^{4

3

5}, Shailja C Shah^{6

3}, Nancy J Brown^{7

8}, T Alp Ikizler^{1

2

3}, Otis D Wilson^{1

3}, Bryce X Rowan⁹, Megan M Shuey¹⁰, Edward D Siew^{1

2

3}, James M Luther⁷, Ayush Giri^{11

5}, Jacklyn N Hellwege¹⁰, Digna R Velez Edwards^{11

12

13}, Christianne L Roumie¹⁴, Ran Tao^{9

5}, Phil S Tsao^{15

16

17}, J Michael Gaziano^{18

19}, Peter W F Wilson^{20

21}, Christopher J O'Donnell^{19

22}, Todd L Edwards^{13

23}, Csaba P Kovesdy^{24

25}, Adriana M Hung^{1

26

2

3}; VA Million Veteran Program

Affiliations

¹ Division of Nephrology and Hypertension, Department of Medicine (E.A.A., C.R.-C., T.A.I., O.D.W., E.D.S., A.M.H.).
² Vanderbilt Center for Kidney Disease (E.A.A., C.R.-C., T.A.I., E.D.S., A.M.H.).
³ Tennessee Valley Healthcare System, Nashville, VA (E.A.A., C.R.-C., C.P.C., S.C.S., T.A.I., O.D.W., E.D.S., A.M.H.).
⁴ Division of Rheumatology, Department of Medicine (C.P.C.), Vanderbilt University Medical Center, Nashville, TN.
⁵ Vanderbilt Genetics Institute (C.P.C., A.G., R.T.).
⁶ Division of Gastroenterology, Hepatology and Nutrition (S.C.S.), Vanderbilt University Medical Center, Nashville, TN.
⁷ Department of Medicine (N.J.B., J.M.L.), Vanderbilt University Medical Center, Nashville, TN.
⁸ Yale School of Medicine, New Haven, CT (N.J.B.).
⁹ Department of Biostatistics, Vanderbilt School of Medicine (B.X.R, R.T.).
¹⁰ Division of Genetic Medicine, Department of Medicine (M.M.S., J.N.H.), Vanderbilt University Medical Center, Nashville, TN.
¹¹ Division of Quantitative Sciences, Department of Obstetrics and Gynecology (D.R.V.E., A.G.), Vanderbilt University Medical Center, Nashville, TN.
¹² Department of Biomedical Informatics (D.R.V.E.), Vanderbilt University Medical Center, Nashville, TN.
¹³ Institute of Medicine and Public Health (D.R.V.E., T.L.E.), Vanderbilt University Medical Center, Nashville, TN.
¹⁴ Veteran Administration Tennessee Valley VA Health Care System Geriatric Research Education Clinical Center (GRECC), Nashville (C.L.R.).
¹⁵ VA Palo Alto Health Care System (P.S.T.).
¹⁶ Department of Medicine, Stanford University School of Medicine, CA (P.S.T.).
¹⁷ Stanford Cardiovascular Institute (P.S.T.).
¹⁸ VA Boston Healthcare System, MA (J.M.G.).
¹⁹ Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (J.M.G., C.J.O.).
²⁰ Epidemiology and Genomic Medicine, Atlanta VAMC, Decatur, GA (P.W.F.W.).
²¹ Cardiology Division, Emory School of Medicine, Atlanta, GA (P.W.F.W.).
²² VA Boston Healthcare System, Section of Cardiology (C.J.O.).
²³ Division of Epidemiology, Department of Medicine (T.L.E.), Vanderbilt University Medical Center, Nashville, TN.
²⁴ Memphis VA Medical Center, TN (C.P.K.).
²⁵ University of Tennessee Health Science Center, Memphis (C.P.K.).
²⁶ Vanderbilt Precision Nephrology Program (A.M.H.), Vanderbilt University Medical Center, Nashville, TN.

Abstract

[Figure: see text].

Keywords: Treatment-resistant hypertension; apolipoprotein L1 variants; end-stage kidney disease; myocardial infarction; race; stroke.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Aged
Antihypertensive Agents / therapeutic use
Apolipoprotein L1 / genetics
Blood Pressure / physiology*
Comorbidity
Female
Genetic Predisposition to Disease
Genotype
Humans
Hypertension / drug therapy
Hypertension / epidemiology*
Hypertension / genetics
Incidence
Kidney Failure, Chronic / epidemiology*
Kidney Failure, Chronic / genetics
Male
Middle Aged
Myocardial Infarction / epidemiology*
Myocardial Infarction / genetics
Retrospective Studies
Veterans

Substances

Antihypertensive Agents
Apolipoprotein L1

Abstract

Publication types

MeSH terms

Substances

Grants and funding