Abstract
p38 MAPKs play a central role in orchestrating the cellular response to stress and inflammation and in the regulation of myogenesis. Potent inhibitors of p38 MAPKs have been pursued as potential therapies for several disease indications due to their antiinflammatory properties, although none have been approved to date. Here, we provide a brief overview of p38 MAPKs, including their role in regulating myogenesis and their association with disease progression. Finally, we discuss targeting p38 MAPKs as a therapeutic approach for treating facioscapulohumeral muscular dystrophy and other muscular dystrophies by addressing multiple pathological mechanisms in skeletal muscle.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Humans
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MAP Kinase Signaling System* / genetics
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MAP Kinase Signaling System* / physiology
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Mice
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Muscle Development / genetics
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Muscle Development / physiology
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Muscle, Skeletal* / metabolism
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Muscle, Skeletal* / physiology
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Muscular Dystrophy, Facioscapulohumeral / genetics
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Muscular Dystrophy, Facioscapulohumeral / metabolism
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Muscular Dystrophy, Facioscapulohumeral / physiopathology
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p38 Mitogen-Activated Protein Kinases* / genetics
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p38 Mitogen-Activated Protein Kinases* / metabolism
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p38 Mitogen-Activated Protein Kinases* / physiology
Substances
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p38 Mitogen-Activated Protein Kinases