Establishing core domain sets for Chronic Nonbacterial Osteomyelitis (CNO) and Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis (SAPHO): A report from the OMERACT 2020 special interest group

Semin Arthritis Rheum. 2021 Aug;51(4):957-961. doi: 10.1016/j.semarthrit.2021.05.015. Epub 2021 Jun 7.

Abstract

Objective: A working group was established to develop a core domain set (CDS) for Chronic Nonbacterial Osteomyelitis (CNO) and Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis (SAPHO) following the OMERACT filter 2.1.

Methods: A scoping review to identify disease-related manifestations was performed, followed by a special interest group (SIG) session at OMERACT2020 to begin the CNO/SAPHO CDS framework.

Results: Candidate items were identified from the scoping review and most fell under Life Impact and Pathophysiology Manifestation core areas. A SIG agreed on the need to develop a CDS for CNO and SAPHO (100%) and for children and adults (91%).

Conclusion: Based on candidate items identified, qualitative research and Delphi surveys will be performed as next steps.

Keywords: Acne; Chronic nonbacterial osteomyelitis; Hyperostosis; OMERACT; Osteitis; Outcome research; Pustulosis; Synovitis.

Publication types

  • Review

MeSH terms

  • Acne Vulgaris*
  • Acquired Hyperostosis Syndrome* / diagnosis
  • Adult
  • Child
  • Humans
  • Hyperostosis*
  • Osteitis*
  • Osteomyelitis* / diagnosis
  • Public Opinion
  • Synovitis*