Anti-PF4 antibody negative cerebral venous sinus thrombosis without thrombocytopenia following immunization with COVID-19 vaccine in an elderly non-comorbid Indian male, managed with conventional heparin-warfarin based anticoagulation

Diabetes Metab Syndr. 2021 Jul-Aug;15(4):102184. doi: 10.1016/j.dsx.2021.06.021. Epub 2021 Jun 24.

Authors

Ajitava Dutta¹, Ritwik Ghosh², Dwaipayan Bhattacharya¹, Saumen Bhat¹, Adrija Ray³, Alak Pandit¹, Shambaditya Das¹, Souvik Dubey⁴

Affiliations

¹ Department of Neuromedicine, Bangur Institute of Neurosciences (BIN), Kolkata, West Bengal, India.
² Department of General Medicine, Burdwan Medical College and Hospital, Burdwan, West Bengal, India.
³ Department of General Medicine, RG Kar Medical College and Hospital, Kolkata, West Bengal, India.
⁴ Department of Neuromedicine, Bangur Institute of Neurosciences (BIN), Kolkata, West Bengal, India. Electronic address: drsouvik79@gmail.com.

No abstract available

Keywords: COVID-19/Vaccination; CVT; ChAdOx1 nCOV-19 (Oxford-AstraZeneca)/COVISHIELD; Thrombocytopenia; VITT.

Publication types

Case Reports

MeSH terms

Anticoagulants / therapeutic use
Autoantibodies / immunology
COVID-19 / prevention & control*
COVID-19 Vaccines / adverse effects*
Cerebral Angiography
ChAdOx1 nCoV-19
Heparin / therapeutic use
Humans
India
Lateral Sinus Thrombosis / chemically induced
Lateral Sinus Thrombosis / diagnostic imaging
Lateral Sinus Thrombosis / drug therapy
Magnetic Resonance Angiography
Male
Middle Aged
Phlebography
Platelet Factor 4 / immunology
SARS-CoV-2
Sagittal Sinus Thrombosis / chemically induced
Sagittal Sinus Thrombosis / diagnostic imaging
Sagittal Sinus Thrombosis / drug therapy
Sinus Thrombosis, Intracranial / chemically induced*
Sinus Thrombosis, Intracranial / diagnostic imaging
Sinus Thrombosis, Intracranial / drug therapy
Thrombocytopenia
Warfarin / therapeutic use

Substances

Anticoagulants
Autoantibodies
COVID-19 Vaccines
PF4 protein, human
Platelet Factor 4
Warfarin
Heparin
ChAdOx1 nCoV-19