Malignant Melanoma within a Cellular Blue Nevi Presenting as a Vascular Malformation and the Connection to Sporadic KRAS Mutations

Felicia Tai; Vitor M Pereira; Sam Babak; Ivan Radovanovic; Shachar Sade; Tara Lynn Teshima

doi:10.1159/000517202

Malignant Melanoma within a Cellular Blue Nevi Presenting as a Vascular Malformation and the Connection to Sporadic KRAS Mutations

Case Rep Dermatol. 2021 Jun 18;13(2):310-316. doi: 10.1159/000517202. eCollection 2021 May-Aug.

Authors

Felicia Tai¹, Vitor M Pereira², Sam Babak³, Ivan Radovanovic⁴, Shachar Sade⁵, Tara Lynn Teshima⁶

Affiliations

¹ Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
² Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
³ Medical Oncology, Markham Stouffville Hospital, Markham, Ontario, Canada.
⁴ Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, Toronto, Ontario, Canada.
⁵ Department of Pathology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
⁶ Division of Plastic and Reconstructive Surgery, Department of Surgery, Markham Stouffville Hospital, Markham, Ontario, Canada.

Abstract

We present a case of malignant melanoma (MM) developing within a vascular malformation showing features of cellular blue nevi. A 47-year-old male presented with acute symptoms of a temporal and zygomatic mass, which were both previously asymptomatic upon development 30 years ago. These masses were diagnosed as vascular malformations upon imaging and were treated with sclerotherapy. Embolization and surgical excision were performed 3 years later due to symptomatic growth. Final pathology reports showed MM with congenital blue nevi. We hypothesize a possible linkage to a sporadic KRAS mutation, linking both presentations of vascular malformation, MM, and cellular blue nevi. A literature search for similar cases is also reported.

Keywords: Blue nevus; KRAS; Melanoma; Nevus; Vascular malformation.

Publication types

Case Reports