Fluid Dynamics of Respiratory Infectious Diseases

Annu Rev Biomed Eng. 2021 Jul 13:23:547-577. doi: 10.1146/annurev-bioeng-111820-025044.

Abstract

The host-to-host transmission of respiratory infectious diseases is fundamentally enabled by the interaction of pathogens with a variety of fluids (gas or liquid) that shape pathogen encapsulation and emission, transport and persistence in the environment, and new host invasion and infection. Deciphering the mechanisms and fluid properties that govern and promote these steps of pathogen transmission will enable better risk assessment and infection control strategies, and may reveal previously underappreciated ways in which the pathogens might actually adapt to or manipulate the physical and chemical characteristics of these carrier fluids to benefit their own transmission. In this article, I review our current understanding of the mechanisms shaping the fluid dynamics of respiratory infectious diseases.

Keywords: COVID-19; aerosols; airborne; fragmentation; host-to-host transmission; infectious diseases; masks; multiphase flows; social distancing; turbulence; ventilation.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aerosols
  • COVID-19 / transmission
  • Communicable Diseases / physiopathology*
  • Communicable Diseases / transmission*
  • History, 19th Century
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Hydrodynamics*
  • Infectious Disease Medicine / history
  • Physical Distancing
  • Respiration Disorders / physiopathology*
  • Respiratory System / physiopathology
  • Respiratory System / virology
  • Rheology
  • SARS-CoV-2
  • Saliva
  • Ventilation

Substances

  • Aerosols