Magnetothermal regulation of in vivo protein corona formation on magnetic nanoparticles for improved cancer nanotherapy

Tingbin Zhang; Galong Li; Yuqing Miao; Junjie Lu; Ningqiang Gong; Yifan Zhang; Yuantai Sun; Yuan He; Mingli Peng; Xiaoli Liu; Xing-Jie Liang; Haiming Fan

doi:10.1016/j.biomaterials.2021.121021

Magnetothermal regulation of in vivo protein corona formation on magnetic nanoparticles for improved cancer nanotherapy

Biomaterials. 2021 Sep:276:121021. doi: 10.1016/j.biomaterials.2021.121021. Epub 2021 Jul 10.

Authors

Affiliations

¹ Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, 710069, China.
² Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, The College of Life Sciences & School of Medicine, Northwest University, Xi'an, 710069, China.
³ Laboratory of Controllable Nanopharmaceuticals, Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, 100190, China.
⁴ Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, 710069, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, The College of Life Sciences & School of Medicine, Northwest University, Xi'an, 710069, China. Electronic address: fanhm@nwu.edu.cn.

PMID: 34274776
DOI: 10.1016/j.biomaterials.2021.121021

Abstract

Engineering the protein corona (PC) on nanodrugs is emerging as an effective approach to improve their pharmacokinetics and therapeutic efficacy, but conventional in vitro pre-programmed methods have shown great limitation for regulation of the PC in the complex and dynamic in vivo physiological environment. Here, we demonstrate an magnetothermal regulation approach that allows us to in situ modulate the in vivo PC composition on iron oxide nanoparticles for improved cancer nanotherapy. Experimental results revealed that the relative levels of major opsonins and dysopsonins in the PC can be tuned quantitatively by means of heat induction mediated by the nanoparticles under an alternating magnetic field. When the PC was magnetically optimized in vivo, the nanoparticles exhibited prolonged circulation and enhanced tumor delivery efficiency in mice, 2.53-fold and 2.02-fold higher respectively than the control. This led to a superior thermotherapeutic efficacy of systemically delivered nanoparticles. In vivo magnetothermal regulation of the PC on nanodrugs will find wide applications in biomedicine.

Keywords: In vivo magnetothermal regulation; Magnetic nanodrug; Pharmacokinetic behavior; Protein corona; Tumor delivery.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Magnetic Fields
Magnetite Nanoparticles*
Mice
Nanoparticles*
Neoplasms* / drug therapy
Protein Corona*

Substances

Magnetite Nanoparticles
Protein Corona