From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

Hui Han; Bao Yi; Ruqing Zhong; Mengyu Wang; Shunfen Zhang; Jie Ma; Yulong Yin; Jie Yin; Liang Chen; Hongfu Zhang

doi:10.1186/s40168-021-01093-y

From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

Microbiome. 2021 Jul 20;9(1):162. doi: 10.1186/s40168-021-01093-y.

Authors

Hui Han^#^{1

2}, Bao Yi^#¹, Ruqing Zhong¹, Mengyu Wang¹, Shunfen Zhang¹, Jie Ma³, Yulong Yin^{3

4}, Jie Yin⁵, Liang Chen⁶, Hongfu Zhang^{7

8}

Affiliations

¹ State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
² Precision Livestock and Nutrition Unit, Gembloux Agro-Bio Tech, University of Liège, Passage de Déportés 2, 5030, Gembloux, Belgium.
³ College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China.
⁴ Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, 410125, China.
⁵ College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China. yinjie2014@126.com.
⁶ State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China. chenliang01@caas.cn.
⁷ State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China. zhanghongfu@caas.cn.
⁸ College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China. zhanghongfu@caas.cn.

^# Contributed equally.

Abstract

Feelings of hunger and satiety are the key determinants for maintaining the life of humans and animals. Disturbed appetite control may disrupt the metabolic health of the host and cause various metabolic disorders. A variety of factors have been implicated in appetite control, including gut microbiota, which develop the intricate interactions to manipulate the metabolic requirements and hedonic feelings. Gut microbial metabolites and components act as appetite-related signaling molecules to regulate appetite-related hormone secretion and the immune system, or act directly on hypothalamic neurons. Herein, we summarize the effects of gut microbiota on host appetite and consider the potential molecular mechanisms. Furthermore, we propose that the manipulation of gut microbiota represents a clinical therapeutic potential for lessening the development and consequence of appetite-related disorders. Video abstract.

Keywords: Appetite; Gut microbiota; Hormone; Immune; Metabolites.

Publication types

Research Support, Non-U.S. Gov't
Review
Video-Audio Media

MeSH terms

Animals
Appetite
Appetite Regulation
Gastrointestinal Microbiome*
Humans
Immune System