Leptin receptor signaling is required for intact hypoglycemic counterregulation: A study in male Zucker rats

J Diabetes Complications. 2021 Oct;35(10):107994. doi: 10.1016/j.jdiacomp.2021.107994. Epub 2021 Jul 15.

Abstract

Hypoglycemia is a major barrier to clinical management of persons with diabetes. Emerging evidence supports a role for leptin in gating hypoglycemic counterregulation. This work demonstrates that male leptin receptor null, Zucker (fa/fa), rats display severe impairments in hypoglycemic counterregulation. Thus, augmenting leptin levels may have clinical utility for preventing hypoglycemia.

Keywords: Diabetes; Hypoglycemia; Leptin; Leptin receptors; Zucker rats.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Glucagon-Like Peptide-1 Receptor
  • Hypoglycemia* / chemically induced
  • Hypoglycemia* / prevention & control
  • Hypoglycemic Agents / pharmacology*
  • Leptin / metabolism*
  • Male
  • Obesity / complications
  • Rats
  • Rats, Zucker
  • Receptors, Leptin* / genetics

Substances

  • Glp1r protein, rat
  • Glucagon-Like Peptide-1 Receptor
  • Hypoglycemic Agents
  • Leptin
  • Receptors, Leptin