Race to the bottom: Darwinian competition in early intestinal tumorigenesis

Cell Stem Cell. 2021 Aug 5;28(8):1340-1342. doi: 10.1016/j.stem.2021.07.008.

Abstract

Mutant oncogenes could enable clonal dominance by cell-intrinsic means or by suppressing nearby wild-type stem cells. Reporting recently in Nature, three groups demonstrate potent neighborhood effects, both within intestinal crypts (Flanagan et al., 2021; van Neerven et al., 2021) and across crypts through intermediary sub-epithelial trophocytes (Yum et al., 2021).

Publication types

  • Comment

MeSH terms

  • Carcinogenesis
  • Cell Transformation, Neoplastic*
  • Humans
  • Intestines*
  • Oncogenes
  • Stem Cells