Linking microbiota composition with antimalarial antibody response

Ottavia Romoli; Liliana Mancio-Silva; Mathilde Gendrin

doi:10.1016/j.pt.2021.07.007

Linking microbiota composition with antimalarial antibody response

Trends Parasitol. 2021 Oct;37(10):853-855. doi: 10.1016/j.pt.2021.07.007. Epub 2021 Aug 11.

Authors

Ottavia Romoli¹, Liliana Mancio-Silva², Mathilde Gendrin³

Affiliations

¹ Microbiota of Insect Vectors Group, Institut Pasteur de la Guyane, Cayenne, French Guiana, France.
² Institut National de la Santé et de la Recherche Médicale, Unité 1201, Paris, France; Biology of Host-Parasite Interactions Unit, Institut Pasteur, Paris, France; Parasites and Insect Vectors Department, Institut Pasteur, Paris, France.
³ Microbiota of Insect Vectors Group, Institut Pasteur de la Guyane, Cayenne, French Guiana, France; Parasites and Insect Vectors Department, Institut Pasteur, Paris, France. Electronic address: mathilde.gendrin@pasteur.fr.

PMID: 34391664
DOI: 10.1016/j.pt.2021.07.007

Abstract

Microbiota composition recently arose as a factor correlating with malaria infection. Mandal et al. showed, via cecal transplant and antibacterial treatment, that the mouse microbiota modulates parasitemia by affecting spleen germinal centers where B cells are matured. They further identified correlations between microbiota composition and malaria severity in Ugandan children.

Keywords: Plasmodium; malaria; microbiota; severity.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Antibody Formation
Antimalarials* / therapeutic use
Malaria* / drug therapy
Mice
Microbiota*
Parasitemia / drug therapy

Substances

Antimalarials