Plasma-activated thermosensitive biogel as an exogenous ROS carrier for post-surgical treatment of cancer

Hao Zhang; Shengduo Xu; Jishen Zhang; Zifeng Wang; Dingxin Liu; Li Guo; Cheng Cheng; Yilong Cheng; Dehui Xu; Michael G Kong; Mingzhe Rong; Paul K Chu

doi:10.1016/j.biomaterials.2021.121057

Plasma-activated thermosensitive biogel as an exogenous ROS carrier for post-surgical treatment of cancer

Biomaterials. 2021 Sep:276:121057. doi: 10.1016/j.biomaterials.2021.121057. Epub 2021 Aug 9.

Authors

Hao Zhang¹, Shengduo Xu¹, Jishen Zhang¹, Zifeng Wang¹, Dingxin Liu², Li Guo¹, Cheng Cheng³, Yilong Cheng⁴, Dehui Xu¹, Michael G Kong⁵, Mingzhe Rong¹, Paul K Chu⁶

Affiliations

¹ State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China.
² State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China. Electronic address: liudingxin@mail.xjtu.edu.cn.
³ Institute of Plasma Physics, Chinese Academy of Sciences, P. O. Box 1126, Hefei, Anhui, 230031, PR China; Department of Physics, Department of Materials Science and Engineering, And Department of Biomedical Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China.
⁴ Department of Applied Physics, School of Science, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China.
⁵ State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China; Department of Electrical and Computer Engineering, Old Dominion University, Norfolk, VA, 23529, USA.
⁶ Department of Physics, Department of Materials Science and Engineering, And Department of Biomedical Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China.

PMID: 34399120
DOI: 10.1016/j.biomaterials.2021.121057

Abstract

Post-surgical residual tumor cells are the primary cause of relapse and progression of cancer but unfortunately, there are limited therapeutic options. In this work, a fillable plasma-activated biogel is produced on a thermosensitive biogel [(Poly-DL-lactide)-(poly-ethylene glycol)-(poly-DL-lactide), PLEL] with the aid of a discharge plasma for local post-operative treatment of cancer. In vivo data show that the plasma-activated PLEL biogel (PAPB) eliminates residual tumor tissues after removal surgery and also inhibits in situ recurrence while showing no evident systemic toxicity. Moreover, the PAPB possesses excellent storage capability, allows for slow release of plasma-generated reactive oxygen species (ROS), and exhibits good ROS-mediated anticancer effects in vitro. Our results reveal that the novel plasma-activated biogel is an effective therapeutic agent for local post-operative treatment of cancer.

Keywords: Plasma-activated biogel; Post-operative tumor treatment; Reactive oxygen species; Surface discharge plasma.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Hydrogels*
Neoplasms* / drug therapy
Reactive Oxygen Species

Substances

Hydrogels
Reactive Oxygen Species