A histochemical study was carried out to evaluate the changes that occur in the glycoproteins of the rat digestive tract following short term treatment with a clay smectite. Staining with the usual methods for detecting complex carbohydrates and with lectin conjugates (Con A, LTA, PNA, SBA and WGA) showed that the stomach was the susceptible organ. Increased staining with LTA and SBA, together with a decrease in the abundance of sulphate groups in the upper mucous neck cells, was observed after the clay treatment. Such treatment induced only slight changes in jejunal and colonic glycoproteins while no modification was observed in the colon. These data suggest that the content of mucus-producing cells could be affected by smectite, even following short-term treatment.