Abstract
The hedgehog pathway, which plays a significant role in embryonic development and stem cell regulation, is activated in gastrointestinal cancers. Chemotherapy is widely used in cancer treatment. However, chemoresistance becomes a substantial obstacle in cancer therapy. This review focuses on the recent advances in the hedgehog pathway's roles in drug resistance of gastrointestinal cancers and the novel drugs and strategies targeting hedgehog signaling.
Keywords:
chemotherapy; colorectal cancer; gastric cancer; pancreatic cancer; resistance; the hedgehog pathway.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antineoplastic Agents / therapeutic use*
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Biomarkers, Tumor / genetics
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Biomarkers, Tumor / metabolism
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Drug Resistance, Neoplasm / drug effects*
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Drug Resistance, Neoplasm / genetics
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Gastrointestinal Neoplasms / drug therapy*
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Gastrointestinal Neoplasms / genetics
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Gastrointestinal Neoplasms / metabolism
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Gene Expression Regulation, Neoplastic / drug effects
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Hedgehog Proteins / genetics
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Hedgehog Proteins / metabolism*
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Humans
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Neoplastic Stem Cells / drug effects
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Neoplastic Stem Cells / metabolism
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Signal Transduction / drug effects*
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Signal Transduction / genetics
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Tumor Microenvironment / drug effects
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Tumor Microenvironment / genetics
Substances
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Antineoplastic Agents
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Biomarkers, Tumor
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Hedgehog Proteins