Whole-Grain Intake in the Mediterranean Diet and a Low Protein to Carbohydrates Ratio Can Help to Reduce Mortality from Cardiovascular Disease, Slow Down the Progression of Aging, and to Improve Lifespan: A Review

Nutrients. 2021 Jul 25;13(8):2540. doi: 10.3390/nu13082540.

Abstract

Increase in the aging population is a phenomenon all over the world. Maintaining good functional ability, good mental health, and cognitive function in the absence of severe disease and physical disability define successful aging. A healthy lifestyle in middle age predisposes successful aging. Longevity is the result of a multifactorial phenomenon, which involves feeding. Diets that emphasize fruit and vegetables, whole grains rather than refined grains, low-fat dairy, lean meats, fish, legumes, and nuts are inversely associated with mortality or to a lower risk of becoming frail among elderly subjects. A regular physical activity and a regular intake of whole grain derivatives together with the optimization of the protein/carbohydrate ratio in the diet, where the ratio is significantly less than 1 such as in the Mediterranean diet and the Okinawan diet, reduces the risk of developing aging-related diseases and increases healthy life expectancy. The purpose of our review was to analyze cohort and case-control studies that investigated the effects of cereals in the diet, especially whole grains and derivatives as well as the effects of a diet with a low protein-carbohydrate ratio on the progression of aging, mortality, and lifespan.

Keywords: aging; carbohydrates; diet; frailty; lifespan; protein; whole grain.

Publication types

  • Review

MeSH terms

  • Aging / physiology*
  • Cardiovascular Diseases / mortality*
  • Cardiovascular Diseases / prevention & control
  • Case-Control Studies
  • Cohort Studies
  • Diet / mortality*
  • Diet, Carbohydrate Loading / mortality
  • Diet, Mediterranean*
  • Diet, Protein-Restricted / mortality
  • Dietary Carbohydrates / administration & dosage
  • Dietary Proteins / administration & dosage
  • Eating / physiology
  • Edible Grain
  • Female
  • Humans
  • Life Expectancy
  • Longevity
  • Male
  • Middle Aged
  • Whole Grains*

Substances

  • Dietary Carbohydrates
  • Dietary Proteins