Metabolism-associated genes in occurrence and development of gastrointestinal cancer: Latest progress and future prospect

Yan-Dong Miao; Lin-Jie Mu; Deng-Hai Mi

doi:10.4251/wjgo.v13.i8.758

Metabolism-associated genes in occurrence and development of gastrointestinal cancer: Latest progress and future prospect

World J Gastrointest Oncol. 2021 Aug 15;13(8):758-771. doi: 10.4251/wjgo.v13.i8.758.

Authors

Yan-Dong Miao¹, Lin-Jie Mu², Deng-Hai Mi¹

Affiliations

¹ The First Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu Province, China.
² The First Affiliated Hospital, Kunming Medical University, Kunming 650000, Yunnan Province, China.

Abstract

Gastrointestinal (GI) cancer remains one of the most prevalent cancers in the world. The occurrence and progression of GI cancer involve multiple events. Metabolic reprogramming is one of the hallmarks of cancer and is intricately related to tumorigenesis. Many metabolic genes are involved in the occurrence and development of GI cancer. Research approaches combining tumor genomics and metabolomics are more likely to provide deeper insights into this field. In this paper, we review the roles of metabolism-associated genes, especially those involved in the regulation pathways, in the occurrence and progression of GI cancer. We provide the latest progress and future prospect into the different molecular mechanisms of metabolism-associated genes involved in the occurrence and development of GI cancer.

Keywords: Colorectal cancer; Gastric cancer; Gastrointestinal cancer; Metabolism-associated genes.

Publication types

Review