Erythrocyte-derived mitochondria take to the lupus stage

Alice Lepelley; Yanick J Crow

doi:10.1016/j.cmet.2021.08.008

Erythrocyte-derived mitochondria take to the lupus stage

Cell Metab. 2021 Sep 7;33(9):1723-1725. doi: 10.1016/j.cmet.2021.08.008.

Authors

Alice Lepelley¹, Yanick J Crow²

Affiliations

¹ Université de Paris, Imagine Institute, Laboratory of Neurogenetics and Neuroinflammation, Inserm UMR, 1163 Paris, France.
² Université de Paris, Imagine Institute, Laboratory of Neurogenetics and Neuroinflammation, Inserm UMR, 1163 Paris, France; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. Electronic address: yanickcrow@mac.com.

PMID: 34496229
DOI: 10.1016/j.cmet.2021.08.008

Abstract

Mitochondria have emerged as critical players in immune homeostasis and disease. Recently in Cell, while characterizing the removal of mitochondria from red blood cells during human erythropoiesis, Caielli et al. highlight the interferon-inducing potential of erythrocyte-derived mitochondria in lupus.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Erythrocytes* / metabolism
Erythropoiesis*
Humans
Mitochondria