GOPC:ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types

Philipp Sievers; Damian Stichel; Martin Sill; Daniel Schrimpf; Dominik Sturm; Florian Selt; Jonas Ecker; Daniel Kazdal; Evelina Miele; Mariëtte E G Kranendonk; Bastiaan B J Tops; Patricia Kohlhof-Meinecke; Rudi Beschorner; Christof M Kramm; Martin Hasselblatt; Guido Reifenberger; David Capper; Pieter Wesseling; Albrecht Stenzinger; Till Milde; Andrey Korshunov; Olaf Witt; Stefan M Pfister; Wolfgang Wick; Andreas von Deimling; David T W Jones; Felix Sahm

doi:10.1007/s00401-021-02369-1

GOPC:ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types

Acta Neuropathol. 2021 Dec;142(6):1065-1069. doi: 10.1007/s00401-021-02369-1. Epub 2021 Sep 18.

Authors

Philipp Sievers^#^{1

2}, Damian Stichel^#^{1

2}, Martin Sill^{3

4}, Daniel Schrimpf^{1

2}, Dominik Sturm^{3

5

6}, Florian Selt^{3

5

7}, Jonas Ecker^{3

5

7}, Daniel Kazdal⁸, Evelina Miele⁹, Mariëtte E G Kranendonk¹⁰, Bastiaan B J Tops¹⁰, Patricia Kohlhof-Meinecke¹¹, Rudi Beschorner¹², Christof M Kramm¹³, Martin Hasselblatt¹⁴, Guido Reifenberger^{15

16}, David Capper^{17

18}, Pieter Wesseling^{10

19}, Albrecht Stenzinger⁸, Till Milde^{3

5

7}, Andrey Korshunov^{1

2

3}, Olaf Witt^{3

5

7}, Stefan M Pfister^{3

4

5}, Wolfgang Wick^{20

21}, Andreas von Deimling^{1

2}, David T W Jones^{3

6}, Felix Sahm^{22

23

24}

Affiliations

¹ Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
² Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
³ Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
⁴ Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁵ Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.
⁶ Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁷ Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
⁸ Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
⁹ Department of Pediatric Onco-Hematology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
¹⁰ Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
¹¹ Department of Pathology, Klinikum Stuttgart, Stuttgart, Germany.
¹² Department of Neuropathology, University of Tübingen, Tübingen, Germany.
¹³ Division of Pediatric Hematology and Oncology, University Medical Center Göttingen, Göttingen, Germany.
¹⁴ Institute of Neuropathology, University Hospital Münster, Münster, Germany.
¹⁵ Institute of Neuropathology, Heinrich Heine University, Düsseldorf, Germany.
¹⁶ German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Düsseldorf, Germany.
¹⁷ Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Neuropathology, Berlin, Germany.
¹⁸ German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁹ Department of Pathology, Amsterdam University Medical Centers, Location VUmc and Brain Tumor Center Amsterdam, Amsterdam, The Netherlands.
²⁰ Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
²¹ Department of Neurology and Neurooncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.
²² Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. felix.sahm@med.uni-heidelberg.de.
²³ Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. felix.sahm@med.uni-heidelberg.de.
²⁴ Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. felix.sahm@med.uni-heidelberg.de.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adaptor Proteins, Signal Transducing / genetics*
Brain Neoplasms / genetics*
Glioma / genetics*
Golgi Matrix Proteins / genetics*
Humans
Molecular Targeted Therapy
Oncogene Fusion / genetics
Oncogene Proteins, Fusion / genetics
Protein-Tyrosine Kinases / genetics*
Proto-Oncogene Proteins / genetics*

Substances

Adaptor Proteins, Signal Transducing
GOPC protein, human
Golgi Matrix Proteins
Oncogene Proteins, Fusion
Proto-Oncogene Proteins
Protein-Tyrosine Kinases
ROS1 protein, human