COVID-19 in Children: Clinical Manifestations and Pharmacologic Interventions Including Vaccine Trials

Ramon Galindo; Heather Chow; Chokechai Rongkavilit

doi:10.1016/j.pcl.2021.05.004

COVID-19 in Children: Clinical Manifestations and Pharmacologic Interventions Including Vaccine Trials

Pediatr Clin North Am. 2021 Oct;68(5):961-976. doi: 10.1016/j.pcl.2021.05.004. Epub 2021 May 18.

Authors

Ramon Galindo¹, Heather Chow¹, Chokechai Rongkavilit²

Affiliations

¹ Department of Pediatrics, University of California San Francisco-Fresno Branch Campus, 155 North Fresno Street, Suite 219, Fresno, CA 93701-2302, USA.
² Department of Pediatrics, University of California San Francisco-Fresno Branch Campus, 155 North Fresno Street, Suite 219, Fresno, CA 93701-2302, USA. Electronic address: chokechai.rongkavilit@ucsf.edu.

Abstract

Children usually present with milder symptoms of COVID-19 as compared with adults. Supportive care alone is appropriate for most children with COVID-19. Antiviral therapy may be required for those with severe or critical diseases. Currently there has been a rapid development of vaccines globally to prevent COVID-19 and several vaccines are being evaluated in children and adolescents. Currently, only the Pfizer-BioNTech messenger RNA vaccine is approved for emergency authorization use in the pediatric population ages 16 years and older.

Keywords: COVID-19; Children; Coronavirus; Infant; SARS-CoV-2; Treatment; Vaccine.

Publication types

Review

MeSH terms

Adolescent
COVID-19 / prevention & control*
COVID-19 Vaccines / therapeutic use*
Child
Humans
Safety
Systemic Inflammatory Response Syndrome / prevention & control*
Vaccines, Synthetic / adverse effects
Vaccines, Synthetic / therapeutic use*

Substances

COVID-19 Vaccines
Vaccines, Synthetic

Supplementary concepts

pediatric multisystem inflammatory disease, COVID-19 related