Microbial metabolites: novel therapeutic tools for boosting cancer therapies

Maik Luu; Alexander Visekruna

doi:10.1016/j.tcb.2021.08.005

Microbial metabolites: novel therapeutic tools for boosting cancer therapies

Trends Cell Biol. 2021 Nov;31(11):873-875. doi: 10.1016/j.tcb.2021.08.005. Epub 2021 Sep 17.

Authors

Maik Luu¹, Alexander Visekruna²

Affiliations

¹ Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany.
² Institute for Medical Microbiology and Hygiene, Philipps-University Marburg, Marburg, Germany. Electronic address: alexander.visekruna@staff.uni-marburg.de.

PMID: 34538658
DOI: 10.1016/j.tcb.2021.08.005

Abstract

The microbiome is a hidden treasure trove comprising various microorganisms that produce a wide range of bioactive molecules. Recent studies provide evidence for the potential impact of microbiota on cancer therapies. Here, we summarize how the molecular interaction of two groups of microbial metabolites with T cells improves immunotherapy for cancer.

Keywords: T cells; cancer; gut microbiota; immunotherapy; microbial metabolites.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Gastrointestinal Microbiome*
Humans
Immunotherapy
Neoplasms* / therapy