Estrogen receptor gets a grip on RNA

Cell. 2021 Sep 30;184(20):5086-5088. doi: 10.1016/j.cell.2021.09.012. Epub 2021 Sep 23.

Abstract

The nuclear hormone receptor estrogen receptor alpha (ERα) is a well-known transcription factor present in many breast cancers, where it promotes cancer progression. In this issue of Cell, Xu et al. report that ERα is also an RNA-binding protein and that its post-transcriptional activity enables cancer cell fitness and survival.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Breast Neoplasms* / genetics
  • Cell Line, Tumor
  • Cell Proliferation
  • Estrogen Receptor alpha / genetics
  • Female
  • Humans
  • RNA / genetics
  • Receptors, Estrogen* / genetics

Substances

  • Estrogen Receptor alpha
  • Receptors, Estrogen
  • RNA